个人简介：
周策凡，亚星会员开户副教授。武汉大学微生物学（生物医药工程方向）博士，武汉市曙光计划获得者，湖北省省级人才。近五年主要基于细胞自噬及Wnt/β-catenin信号通路对肿瘤发生、转移的分子机制及相关分子药物方向展开研究。以第一或通讯作者在Molecular Cancer、Autophagy(2篇)、Cell Insight、Cell Death Disease、Cell Commun Signal等期刊发表多篇SCI论文。授权国家发明专利5项。国家外专局/教育部细胞调控与分子药物“111”引智基地办公室主任，国家自然科学基金评审专家、深圳市科创委基础研究专项、成都市科技局科技专项评审专家。中国细胞生物学学会（CSCB）、美国癌症协会（AACR）、美国科学促进会（AAAS）、加拿大分子生物科学学会及中国生物化学与分子生物学学会（CSBMB）会员。
主要学术成果包括：①利用细胞及斑马鱼模型阐明了STYK1、TSPAN1以及RUNDC1等因子通过Ⅲ类磷脂酰肌醇3-激酶（PtdIns3K-C1）及SNARE复合体促进细胞自噬起始和融合的分子机制；②阐明了FAM83A、STYK1以及LncRNA-PVT1等因子对Wnt/β-catenin及自噬信号通路的互作机制，及其对胰腺癌发生、发展和耐药的分子机理；③聚焦胰腺癌Kras级联信号联合自噬或Wnt/β-catenin信号通路的交叉协同及治疗策略。
招生信息
1.招生学科：生物工程、生物与医药、药学
2.研究方向：细胞自噬与信号转导/多肽药物设计
3.招生年度：2023
科研项目
1.国家自然科学基金面上项目：STYK1通过Wnt/β-catenin信号通路调控胰腺癌吉西他滨耐药的分子机制研究，32270768，2023-2026，主持。
2.湖北省科技厅国际科技合作项目，基于胰腺癌WNT信号通路靶向短肽药物的研发及临床前评价，2023-2025，主持。
3.武汉市科技局曙光计划，项目批准号：2022020801020272，2022-2024，主持。
4.国家自然科学基金青年基金，LncRNA-PVT1通过Pygo2调控细胞自噬在胰腺癌吉西他滨耐药中的分子机制研究，31701228，2018-2020，主持。
5.亚星会员开户启动基金，LC3相互作用蛋白的鉴定及其通过自噬在胰腺癌进程中的分子机制研究，BSQD2020035，2020-2022，主持。
成果获奖
1. Zhou Cefan, Dong Xueying, Wang Ming, Qian Xuehong, Hu Miao, Liang Kai, Liang Yanyan, Zhang Rui, Huang Yuan, Lyu Hao, Xiao Shuai, Tang Yongfei, Ali Declan, Michalak Marek, Chen Xing-Zhen and Tang Jingfeng*. Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.Cell Insight. 1(4): 100045.2022 (IF:-)
2. Huang Yuan, Li Shi, Liu Qinfeng, Wang Zhiije, Li Shunyao, Liu Lei, Zhao Weiwei, Wang Kai, Zhang Rui, Wang Longfei, Wang Ming, Ali Declan, Michalak Marek, Chen Xing-Zhen,Zhou Cefan*(共同通讯)& Tang Jingfeng*. The LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy.Cell Death & Disease.13(6):524.2022 (IF: 9.685)
3.Zhou Cefan, Liang Yanyan, Zhou Li, Yan Yanan, Liu Nanxi, Zhang Rui, Huang Yuan, Wang Ming, Tang Yu, Ali Declan, Wang Yefu, Michalak Marek, Chen Xing-Zhen, Tang Jingfeng*. TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.Autophagy. 17(10):3175-3195.2021 (IF: 13.391)
4.Zhou Cefan, Yi Changhua, Yi Yongxiang, Qin Wenying, Yan Yanan, Dong Xueying, Zhang Xuewen, Huang Yuan, Zhang Rui, Wei Jie, Ali Declan, Michalak Marek, Chen Xing-Zhen, Tang Jingfeng*. LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.Molecular Cancer. 29;19(1):118.2020 (IF: 41.444)
5.Zhou Cefan, Qian Xuehong, Hu Miao, Zhang Rui, Liu Nanxi, Huang Yuan, Yang Jing, Zhang Juan, Bai Hua, Yang Yuyan, Wang Yefu, Ali Declan, Michalak Marek, Chen Xing-Zhen, Tang Jingfeng*. STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I.Autophagy. 16(10):1786-1806.2020 (IF: 13.391)
6.Zhou Cefan, Wang Ming, Yang Jing, Xiong Hui, Wang Yefu, Tang Jingfeng*. Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.Cell Commun Signal. 22;17(1):105.2019 (IF: 7.525)
7.Zhou Cefan, Zhang Yi, Dai Jun, Zhou Mengzhou, Liu Miao, Wang Yefu, Chen Xing-Zhen, Tang Jingfeng*. Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.Sci Rep. Feb 23;6:22066.2016 (IF: 4.996)
8.Zhou Cefan, Wang Ming, Zhou Li, Zhang Yi, Liu Weiyong, Qin Wenying, He Rong, Lu Yang, Wang Yefu, Chen Xing-Zhen, Tang Jingfeng*. Prognostic significance of PLIN1 expression in human breast cancer.Oncotarget. Aug 23;7(34):54488-54502. 2016
9. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M ,...Zhou Cefan...et al., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).Autophagy. Jan 17(1):1-382.2021
10. Huang Yuan, Li Shunyao, Jia Zhenhua, Li Shi, He Wenzao,Zhou Cefan, Zhang Rui, Xu Rui, Sun Bo, Ali Declan, Michalak Marek, Chen Xing-Zhen, Tang Jingfeng*. TRIM4 interacts with TRPM8 and regulates its channel function through K423-mediated ubiquitination.J Cell Physiol. 236(4):2934-2949.2021
11. Huang Yuan, Li Shi, Jia Zhenhua, Zhao Weiwei,Zhou Cefan, Zhang Rui, Ali Declan, Michalak Marek, Chen Xing-Zhen, Tang Jingfeng*. Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy.Front Oncol. 10:573127.2020
